In questi due studi svedesi il rischio (OR) di cancro al cervello aumenta fino a tre volte per un uso complessivo sopra le 100 ore e per più di 25, particolarmente se l'uso del cellulare inizia prima dei 20 anni
Traduzione italiana (L Giuliani)
Cellulari e cordless: rischio di glioma - Analisi combinata di studi caso-controllo in Svezia, 1997-2003 e 2007-2009,
Titolo originale e riferimenti bibliografici:
L.Hardell, M. Carlberg, Cell and cordless phone risk for glioma - Analysis of pooled case-control studies in Sweden, 1997-2003 and 2007-2009, Pathophysiology (2014), Available online 29 October 2014.
Recensione: Joel M. Moskowitz, Ph.D.Director, Center for Family and Community Health School of Public Health, University of California, Berkeley Center: http://cfch.berkeley.edu
Traduzione: Livio Giuliani, dirigente di ricerca del Servizio Sanitario Nazionale, ICEMS Spokesman
Riassunto
E' stata compiuta un'analisi combinata di 2 studi caso-controllo sui tumori cerebrali maligni in pazienti diagnosticati durante i periodi 1997-2003 e 2007-2009. Età 20-80 anni e 18-75 anni, rispettivamente, al momento della diagnosi. Sono stati inclusi solo i casi con verifica istopatologica del tumore. Sono stati impiegati controlli di popolazione, abbinati a età e sesso,. Le esposizioni sono state valutate mediante questionario. L'intero gruppo di riferimento è stato utilizzato per l'analisi di regressione incondizionata aggiustato per sesso, età, anno di diagnosi e indice socio-economico.
In totale hanno partecipato 1.498 (89%) casi e 3.530 (87%) controlli. L'uso del telefono cellulare aumenta il rischio di glioma generale, OR = 1.3, 95% CI = 1,1-1,6; incrementando fino a OR = 3.0, 95% CI = 1,7-5,2 nel gruppo di latenza> 25 anni. L'utilizzo di telefoni cordless aumenta il rischio, OR = 1.4, 95% CI = 1,1-1,7, con un rischio più alto nel gruppo di latenza> 15-20 anni raggiungendo OR = 1.7, 95% CI = 1,1-2,5. L'OR è risultato aumentato in modo statisticamente significativo sia per 100 h di uso cumulativo, sia per anno di latenza nell'uso del telefono cellulare e cordless. L'OR complessivo più alto si è trovato per l'uso ipsilaterale del telefono cellulare o cordless, OR = 1.8, 95% CI = 1,4-2,2 e OR = 1.7, 95% CI = 1,3-2,1, rispettivamente. Il rischio più alto è stato trovato per il glioma nel lobo temporale. L'uso precoce di telefoni cellulari o cordless prima dei 20 anni ha dato un rischio più alto per il glioma che nelle fasce di età successive.
In totale hanno partecipato 1.498 (89%) casi e 3.530 (87%) controlli. L'uso del telefono cellulare aumenta il rischio di glioma generale, OR = 1.3, 95% CI = 1,1-1,6; incrementando fino a OR = 3.0, 95% CI = 1,7-5,2 nel gruppo di latenza> 25 anni. L'utilizzo di telefoni cordless aumenta il rischio, OR = 1.4, 95% CI = 1,1-1,7, con un rischio più alto nel gruppo di latenza> 15-20 anni raggiungendo OR = 1.7, 95% CI = 1,1-2,5. L'OR è risultato aumentato in modo statisticamente significativo sia per 100 h di uso cumulativo, sia per anno di latenza nell'uso del telefono cellulare e cordless. L'OR complessivo più alto si è trovato per l'uso ipsilaterale del telefono cellulare o cordless, OR = 1.8, 95% CI = 1,4-2,2 e OR = 1.7, 95% CI = 1,3-2,1, rispettivamente. Il rischio più alto è stato trovato per il glioma nel lobo temporale. L'uso precoce di telefoni cellulari o cordless prima dei 20 anni ha dato un rischio più alto per il glioma che nelle fasce di età successive.
L'OR complessivo più alto si è trovato per l'uso ipsilaterale del telefono cellulare o cordless, OR = 1.8, 95% CI = 1,4-2,2 e OR = 1.7, 95% CI = 1,3-2,1, rispettivamente. Il rischio più alto è stato trovato per glioma nel lobo temporale. L'uso precoce di telefoni cellulari o cordless prima dei 20 anni ha dato più alto rischio per il glioma che nelle fasce di età successive.
Cell and cordless phone risk for glioma - Analysis of pooled case-control studies in Sweden, 1997-2003 and 2007-2009
L. Hardell, M. Carlberg, Cell and cordless phone risk for glioma - Analysis of pooled case-control studies in Sweden, 1997-2003 and 2007-2009, Pathophysiology (2014), Available online 29 October 2014. http://dx.doi.org/10.1016/j.pathophys.2014.10.001
Abstract
We made a pooled analysis of 2 case-control studies on malignant brain tumours with patients diagnosed during 1997-2003 and 2007-2009. They were aged 20-80 years and 18-75 years, respectively, at the time of diagnosis. Only cases with histopathological verification of the tumour were included. Population-based controls, matched on age and gender, were used. Exposures were assessed by questionnaire. The whole reference group was used in the unconditional regression analysis adjusted for gender, age, year of diagnosis and socio-economic index.
In total 1,498 (89%) cases and 3,530 (87%) controls participated. Mobile phone use increased the risk of glioma, OR = 1.3, 95% CI = 1.1-1.6 overall, increasing to OR = 3.0, 95% CI = 1.7-5.2 in the > 25 year latency group. Use of cordless phones increased the risk to OR = 1.4, 95% CI = 1.1-1.7, with highest risk in the >15-20 year latency group yielding OR = 1.7, 95% CI = 1.1-2.5. The OR increased statistically significant both per 100 h of cumulative use, and per year of latency for mobile and cordless phone use. Highest ORs overall were found for ipsilateral mobile or cordless phone use, OR = 1.8, 95% CI = 1.4-2.2 and OR = 1.7, 95% CI = 1.3-2.1, respectively. The highest risk was found for glioma in the temporal lobe. First use of mobile or cordless phone before the age of 20 gave higher OR for glioma than in later age groups.
http://www.journals.elsevier.com/pathophysiology/
L. Hardell, M. Carlberg, Cell and cordless phone risk for glioma - Analysis of pooled case-control studies in Sweden, 1997-2003 and 2007-2009, Pathophysiology (2014), Available online 29 October 2014. http://dx.doi.org/10.1016/j.pathophys.2014.10.001
Abstract
We made a pooled analysis of 2 case-control studies on malignant brain tumours with patients diagnosed during 1997-2003 and 2007-2009. They were aged 20-80 years and 18-75 years, respectively, at the time of diagnosis. Only cases with histopathological verification of the tumour were included. Population-based controls, matched on age and gender, were used. Exposures were assessed by questionnaire. The whole reference group was used in the unconditional regression analysis adjusted for gender, age, year of diagnosis and socio-economic index.
In total 1,498 (89%) cases and 3,530 (87%) controls participated. Mobile phone use increased the risk of glioma, OR = 1.3, 95% CI = 1.1-1.6 overall, increasing to OR = 3.0, 95% CI = 1.7-5.2 in the > 25 year latency group. Use of cordless phones increased the risk to OR = 1.4, 95% CI = 1.1-1.7, with highest risk in the >15-20 year latency group yielding OR = 1.7, 95% CI = 1.1-2.5. The OR increased statistically significant both per 100 h of cumulative use, and per year of latency for mobile and cordless phone use. Highest ORs overall were found for ipsilateral mobile or cordless phone use, OR = 1.8, 95% CI = 1.4-2.2 and OR = 1.7, 95% CI = 1.3-2.1, respectively. The highest risk was found for glioma in the temporal lobe. First use of mobile or cordless phone before the age of 20 gave higher OR for glioma than in later age groups.
http://www.journals.elsevier.com/pathophysiology/
Key Findings
The relative risk of glioma for wireless (cell and cordless) phone use increased from 1.3 (95% CI = 1.1-1.6) for more than 1 year of use to 3.0 (95% CI = 1.7-5.2) for more than 25 years of use (Table 2).
The ipsilateral (same side of head where phone was used) relative risk of gloma for cell phone use increased from 1.8 (95% CI = 1.4-2.2) for more than 1 year of use to 4.6 (95% CI = 2.1-10.0) for more than 25 years of use (Table 5).
The contralateral (opposite side of head where phone was used) relative risk of gloma for cell phone use increased from 1.1 (95% CI = 0.8-1.4) for more than 1 year of use to 3.2 (95% CI = 1.2-8.6) for more than 25 years of use (Table 5).
The ipsilateral (same side of head where phone was used) relative risk of gloma for cell phone use increased from 1.8 (95% CI = 1.4-2.2) for more than 1 year of use to 4.6 (95% CI = 2.1-10.0) for more than 25 years of use (Table 5).
The contralateral (opposite side of head where phone was used) relative risk of gloma for cell phone use increased from 1.1 (95% CI = 0.8-1.4) for more than 1 year of use to 3.2 (95% CI = 1.2-8.6) for more than 25 years of use (Table 5).
The overall relative risk of glioma for 1-122 hours of wireless phone use was 1.2 (95% CI = 0.9-1.4) whereas the risk for more than 1,486 hours was 2.0 (95% CI = 1.6-2.6) (Table 6).
The ipsilateral relative risk of glioma for people who first used mobile phones at less than 20 years of age was 2.3 (95% CI =1.3-4.2) whereas the risk for those who first used mobile phones at 50 years of age or older was 1.7 (95% CI =1.3-2.2) (Table 8).
Conclusion. We previously analysed the evidence on glioma associated with the use of wireless phones using the Hill criteria [20]. We concluded that glioma and also acoustic neuroma are caused by RF-EMF emissions from wireless phones, and thus regarded as carcinogenic, under Group 1 according to the IARC classification, indicating that current guidelines for exposure should be urgently revised. This pooled analysis gives further support to that conclusion regarding glioma. --
Joel M. Moskowitz, Ph.D.
Director, Center for Family and Community Health
School of Public Health, University of California, Berkeley
Center: http://cfch.berkeley.edu
Electromagnetic Radiation Safety
Website: http://www.saferemr.com
Facebook: http://www.facebook.com/SaferEMR
News Releases: http://pressroom.prlog.org/jmm716/
Twitter: @berkeleyprc
Joel M. Moskowitz, Ph.D.
Director, Center for Family and Community Health
School of Public Health, University of California, Berkeley
Center: http://cfch.berkeley.edu
Electromagnetic Radiation Safety
Website: http://www.saferemr.com
Facebook: http://www.facebook.com/SaferEMR
News Releases: http://pressroom.prlog.org/jmm716/
Twitter: @berkeleyprc
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